Laboratory of Physical and Chemical Biology of Membrane Proteins ​

IBPC
CNRS
Université Paris Cité

Our laboratory gathers biologists, physicists and chemists who are interested in the structure, structural dynamics and physical chemistry of membrane proteins, either in membrane mimetic systems (liposomes or nanodiscs), or in classical detergent solutions or alternative surfactants such as amphipols.

Following the footsteps of Jean Perrin who created the institute together with Baron Edmond de Rothschild, we develop fundamental, interdisciplinary research for health and environment.

This team is Amazing

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Our research themes

Research within the laboratory is organized in four main themes.

Energy coupling
& supramolecular organization of respiratory chain complexes

Molecular pathway
of GPGRs

Transport
& membrane dynamics
in bacteria

Molecular synthesis of Amphipols and ligands
& biophysical approaches

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Tool Box Development

In addition, all members of the unit contribute to the development of our tool box for membrane proteins studies, which includes: NMR, mass spectrometry, crystallography, physical-chemistry of surfactants, membrane protein production and synthetic biology.

Bacterial hosts for
membrane protein
production
The lab has a a long-standing history of designing bacterial hosts adapted
to membrane protein production within the T7 expression system.
More recently we engineered new bacterial hosts with modified
membrane lipid composition.

All bacterial hosts are available upon request.
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Amphipols
New amphipathic polymer
for membrane protein
extraction and solubilisation
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IBPC Core Facility
The IBPC has a long culture of sharing
of scientific equipments necessary
for addressing scientific questions
and integrating new approaches.
Technological equipment is grouped
in innovative and efficient core facility.
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FP-DYNAMO-PARIS FELLOWSHIP PROGRAMME

The programme is proposing 21 fellowships for the most brilliant students from all over the world.

This project is funded by the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie actions (grant agreement No 101034407).

In our laboratory, there will be 4 fellowship topics.


Fellowship
Study of the energy landscape
of G protein-coupled receptors
PIs:
L.J. Catoire,
K. Moncoq
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Fellowship
SyBOrg, creating a synthetic membrane organelle in E. Coli and C. reinhardtii
PI: F.Zito, B.Miroux
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Heme import in bacteria:
structural studies of
transmembrane protein
complexes
PI: V. Biou, N. Dautin, P. Delepelaire
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Structure function study of a tripartite efflux pump from the ABC superfamily, in its lipid environment
PI: Martin Picard, Manuela Zoonens
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Why join us ?

12 Videos

Post-doc Testimonies

Membrane & Molecules Seminars

Facts and Figures

Research is a collective adventure where cohesion of the team is essential. We foster social activities to stimulate exchange of expertise, mentoring and synergies between research topics. Social life around the Institute is highly attractive for students and early researchers.

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People
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Trained students
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IBPC
CNRS
Université Paris Cité